Enclomiphene Citrate Solution 12.5mg/ml , 50ml

Enclomiphene Citrate Solution 12.5mg/ml – 50mlApplicationSelective Estrogen Receptor Modulator (SERM)Concentration12.5 mg/mLCompositionPEG 400, DMSO (10%)AppearanceClear, colorless to faint yellow solutionCAS7599-79-3Molar Mass598.08 g/molChemical FormulaC32H36ClNO8SynonymsEnclomiphene Citrate, trans-Clomiphene CitrateStorageStore at 20–25°C. Minimize air exposure. Protect from light and moisture.TermsFor laboratory research use only. Not for human or animal consumption.What Is Enclomiphene Citrate?Enclomiphene citrate is the trans-isomer of clomiphene and a selective estrogen receptor modulator (SERM) that acts as an estrogen receptor antagonist at the hypothalamic level. By blocking negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, enclomiphene increases the pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulates testicular testosterone production. This mechanism distinguishes it from testosterone replacement therapy (TRT), which suppresses the HPG axis.Enclomiphene has been studied in multiple Phase 2 and Phase 3 clinical trials for secondary male hypogonadism, where it demonstrated the ability to restore normal testosterone levels while maintaining or improving sperm counts — a meaningful clinical advantage over TRT for men who wish to preserve fertility.Mechanism: HPG Axis RestorationClomiphene consists of two isomers: the cis-isomer (zuclomiphene) has weak estrogenic agonist activity, while the trans-isomer (enclomiphene) is the pharmacologically active antagonist component. By isolating enclomiphene from the racemic mixture, researchers have access to a cleaner pharmacological tool for studying hypothalamic estrogen receptor antagonism and its downstream effects on the reproductive endocrine axis.Research ApplicationsSecondary hypogonadism: Restoration of endogenous testosterone via HPG axis stimulation.Male fertility: Unlike TRT, enclomiphene typically increases or maintains sperm count while elevating testosterone.Endocrinology: Research into estrogen receptor subtypes in the hypothalamus and their role in HPG axis regulation.Comparative SERM pharmacology: Studies examining the differences between enclomiphene, tamoxifen, and other SERMs in central versus peripheral ER activity.Related CompoundsEnclomiphene is studied alongside RAD-140 (Testolone) and LGD-4033 in research designs examining testosterone axis modulation from different angles — SARMs directly activate the androgen receptor while enclomiphene stimulates endogenous androgen production via the HPG axis. For reference on the most studied SARM in clinical settings, see MK-2866 (Ostarine).Note: Supplied in HDPE bottle due to DMSO solvent compatibility. Filled content is 50 mL for all units.For laboratory research use only. Not for human or animal consumption.